Complications of Antiretroviral Drugs

NIAID Research on the Complications of Antiretroviral Drugs
NIAID supports studies aimed at understanding the side effects of antiretroviral drugs as well as strategies to reduce exposure to potentially toxic drug regimens, such as:

• Structured treatment interruption (STI) protocols.


• Use of immune-based therapies with HAART


• Studies to compare different drug dosing schedules or combinations


• Studies to compare early versus delayed treatment
  

NIAID also supports projects evaluating regimens containing agents associated with toxicities. For example, NIAID-funded researchers are conducting studies to evaluate treatments for several drug-associated metabolic complications, including fat redistribution, lipid and glucose abnormalities, and bone loss. In addition, researchers are studying the long-term metabolic effects of various antiretroviral regimens in pregnant women and their infants and in HIV-infected children and adolescents.